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Description
AXIN1 Polyclonal Antibody. This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling domain and a dishevelled and axin domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants enc
Immunogen
n/a
Other Names
AXIN1; axin 1; AXIN; LA16c-314G4.3; MGC52315; axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of