A hydrophobic derivative of deoxynojirimycin that potently inhibits β-glucosidase 2 (IC50 = 0.3 nM), less potently antagonizes glucosylceramide synthase (IC50 = 25 nM), but only poorly inhibits other GCase isoforms; suppresses hapten-induced colitis, enhances insulin sensitivity, and induces SREBP-regulated gene expression and cholesterol synthesis.