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Description
Rabbit Anti-Mouse NR2F2 polyclonal antibody for IHC-P, WB, ChIP, IF. COUP transcription factor 2 (UniProt P43135; also known as Apolipoprotein AI regulatory protein 1, Apolipoprotein regulatory protein 1, ARP-1, COUP-TF II, COUP transcription factor II, Nuclear receptor subfamily 2 group F member 2) is encoded by the Nr2f2 (also known as Aporp1, Arp-1, Arp1, Tfcoup2) gene (Gene ID 11819) in murine species. COUP transcription factors1&2 (COUP-TFI & COUP-TFII) are two related nuclear orphan receptors implicated in their roles in guiding migrating neurons towards their target regions during brain development. COUP-TFI and COUP-TFII are expressed in distinct and non-overlapping migrating cells in specific pathways in the basal telencephalon of mouse embryos at a stage when interneuron migration is robust. While COUP-TFI appears to control dorsal and ventral migration in the basal telencephalon, COUP-TFII is more specific in modulating tangential migration into the intermediate zone of the cortex. Coup-TFII is also identified as an activator of Prox1 expression in venous lymphatic endothelial cell (LEC) progenitors during early stages of LEC specification and differentiation.