Recombinant Human Mixed lineage kinase domain-like protein (MLKL)
Description
Purity > 90% as determined by SDS-PAGE. MW: 70.5kDa. Full Length: 1-471aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma mbrane and execution of programmed necrosis characterized by calcium influx and plasma mbrane damage. Does not have protein kinase activity.