A selective, cell-permeable, quinolone-based inhibitor of Chk1 (IC50 = 0.3 nM versus 0.7 μM for Chk1 and Chk2, respectively); inhibits p53-mutant solid tumor cell growth in synergy with topoisomerase I poisons or ionizing radiation, potentiating tumor apoptosis
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
checkpoint 1 kinase inhibitor Chk1 topoisomerases I radiosensitizations p53 cells cycles antitumor anti-tumor apoptosis cancer DNA damage repair biochemical selective CHIR-124 permeable quinolone-based in vitro selective selectivity inhibit poison ionizing radiations growth mutant solid tumor xenograft model potentiate