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Description
Polyclonal antibody to detect TONSL in human samples. The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.
Immunogen
Recombinant protein of human TONSL
Other Names
I-kappa-B-related protein, IKBR, NFBIL2/TONSL, NFKBIL2, MMS22L-interacting protein