bovine, canine, equine, guinea pig, human, mouse, rabbit, rat, zebrafish
Isotype
n/a
Format
purified
Size
100 μl
Concentration
n/a
Applications
Western Blot: 1.0 μg/mL
Reviews / Ratings
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Description
Acinus Polyclonal Antibody. Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been
Immunogen
n/a
Other Names
ACINUS, ACN, fSAP152; apoptotic chromatin condensation inducer in the nucleus; functional spliceosome-associated protein 152