Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:1000
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Description
RAP1GAP Polyclonal Antibody. Rap1 GTPase activating protein (Rap1GAP) specifically stimulates GTP hydrolytic activity of the monomeric G protein Rap1. Physical interaction between G alpha z, a member of the Gi family of trimeric G proteins, and Rap1GAP blocks the ability of regulators of G protein signaling to stimulate GTP hydrolysis of the alpha subunit, and also attenuates the ability of activated G alpha z to inhibit adenylyl cyclase. Rap1GAP is expressed in the brain, kidney and pancreas and may act as a signal integrator to coordinate and/or integrate Gz signaling and Rap1 signaling in cells. A novel isoform of Rapl GTPase-activating protein, designated Rap1GAPII, binds specifically to G alpha z. Stimulation of the Gi-coupled M2 Musca
Immunogen
n/a
Other Names
Rap1 GTPase-activating protein 1, Rap1GAP, Rap1GAP1, KIAA0474, RAP1GA1