27-145aa; Extracellular Domain. MW: 29.6kD. Purity >90% as determined by SDS-PAGE. This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor.
Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.Usdin T.B., Gruber C., Bonner T.I.J. Biol. Chem. 270:15455-15458(1995) cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).King M.M., Aronstam R.S., Sharma S.V. Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization.Usdin T.B., Modi W., Bonner T.I.Genomics 3