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Description
Rabbit Anti-Rat SPFH2 polyclonal antibody for WB, IP, ICC. Erlin-2 (UniProt B5DEH2; also known as Endoplasmic reticulum lipid raft-associated protein 2, SPFH domain-containing protein 2, SPFH domain family member 2, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) is encoded by the Erlin2 (also known as RGD1309010, Spfh2) gene (Gene ID 290823) in rat species. Erlin2 (Spfh2) and the highly homologous Erlin1 (Spfh1) are ER proteins that hetero-oligomerize into a large complex of ?2 MDa. The erlin1/2 complex associates with inositol 1,4,5-trisphosphate (IP(3)) receptors on ER membrane and is responsible for recruiting RNF170 upon IP(3) receptor activation for subsequent ubiquitination-dependent receptor downregulation.
Immunogen
KLH-conjugated linear peptide corresponding to the C-terminus of rat ERLIN-2/SPFH2.