Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting 4 Protein (PIN4) (AA 1-156) protein
Description
Recombinant Human Parvulin-14/PIN4 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Lys156) of Human PIN4 fused with a 6His tag at the N-terminus. Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4(PIN4) is a peptidyl-prolyl cis/trans isomerase (PPIase) which interacts with NIMA and is vital for cell cycle regulation. PIN4 has 2 different isoforms: PAR14 and PAR17. Furthermore, PIN4 protein binds to double-stranded DNA under physiological salt conditions. PIN4 is involved as a ribosomal RNA processing factor in ribosome biogenesis. The PAR14 binds to tightly bent AT-rich stretches of double-stranded DNA, but PAR17 binds to double-stranded DNA.