An inhibitor of ACC1 and ACC2 (IC50s = 2.1 and 6.1 nM, respectively, for the human enzymes); inhibits ACC dimerization; selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 μM; reduces fatty acid synthesis in HepG2 cells (EC50s = 66 and 9 nM in 10% FBS and serum-free media, respectively); reduces hepatic steatosis, improves glucose-stimulated insulin secretion, and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats