A small molecule that at 1-25 μM improves ER protein-folding ability, stimulates the expression of multiple chaperone proteins, and induces phosphorylation of eIF2α to reduce protein synthesis; exerts antidiabetic activity in both ob/ob and diet-induced obese mice at 150 mg/kg, improving insulin sensitivity and glucose homeostasis, as well as protecting pancreatic β cells against ER stress
Size
25 mg
Concentration
n/a
Applications
n/a
Other Names
unfolded protein response UPR protein endoplasmic reticulum folding chaperone ER stress