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Description
PE anti-mouse Ly49H. Ly49H, also known as Cmv1 and Klra8, is a 28.3 kD protein.? It is expressed on NK cells (but not on NKT cells) from C57BL/6 mice (but not Balb/c or DBA/2 mice).? Expression of Ly49H has been associated with resistance to MCMV infection in C57BL/6 mice.? Modulation of Ly49H expression by its antibody made MCMV-resistant C57BL/6 mice susceptible to infection.? Unlike Ly49A, Ly49H lacks the ITIM (immunoreceptor tyrosine-based inhibitory motif) but has ITAM (immunoreceptor tyrosine-based activation motif), which is associated with DAP-12 (KARAP, killer cell activating motif).?