ENPP6 (ectonucleotide phosphodiesterase/pyrophosphatase member 6) is a choline-specific glycerophosphodiester phosphodiesterase that is part of the Nucleotide pyrophosphatases/phosphodiesterases (NPPs) family.? The NPPs are ubiquitous membrane-associated or secreted ectoenzymes. The NPP family is conserved in vertebrates and the mammals have seven structurally-related ecto-enzymes. The ENPP family is divided in two groups ENPP1–3 and ENPP4–7.? ENPP1–3 are multidomain proteins consisting of two N-terminal somatomedin B-like domains, a central phosphodiesterase (PDE) catalytic? domain, and a C-terminal nuclease-like domain, whereas ENPP4–7 have only the PDE domain in common. In vitro, ENPP6 has phosphodiesterase activity to choline-containing compounds such as glycerophosphorylcholine (GPC) and O-phosphorylcholine N-acyl ethanolamine to produce phosphocholine. In addition, ENPP6 hydrolyzes choline-containing lysophospholipids, such as lysophophocolin (LPC), sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF), and lysoPAF. Enpp6 has an active-site pocket that recognizes the choline head group of LPC substrates.? ENPP6 is bound to the plasma membrane through its C-terminal glycosylphosphatidylinositol (GPI) anchor; also, the soluble form of ENPP6 has been identified.
Size
25 μg
Concentration
n/a
Applications
BA
Other Names
Ectonucleotide Pyrophosphatase, Phosphodiesterase Family Member 6, NPP6, GPC-Cpde, Ectonucleotide Pyrophosphatase, Phosphodiesterase 6