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Description
AXL Polyclonal Antibody, HRP Conjugated. ? Target Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1,
Immunogen
KLH conjugated synthetic peptide derived from human AXL. Immunogen Range: 180-230/894
Other Names
UFO; JTK11; Tyrosine-protein kinase receptor UFO; AXL oncogene; AXL