1-539aa, Full length protein. MW: 60,400 Da. Purity >85% (SDS-PAGE). This gene encodes a member of the receptor-interacting protein (RIP) family of serinethreonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.