1-486aa, full length protein. MW: 53,322 Da. Purity >85% (SDS-PAGE). The product of this gene is a member of the receptor-interacting protein (RIP) family of serinethreonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I s