An antagonist of neuronal nicotinic AChRs (Ki = 0.055 μM); selective for neuronal nAChRs over muscle-type AChRs (Ki = 70 μM); inhibits acetylcholine-evoked currents in Xenopus oocytes expressing chick α7 subunit-containing nAChRs (IC50 = 95 nM); selective for α7 subunit-containing nAChRs over α6, β2, and β4 subunit-containing nAChRs (Kis = 4.52, 12, and 9.2 μM, respectively); decreases vagus nerve stimulation-induced contractions of isolated guinea pig vagus nerve-stomach preparations (EC50 = 49.4 μM); decreases Egr-1 protein levels in and proliferation of HMEC-Ls; decreases angiogenesis in vitro, ex vivo, and in an H69 SCLC mouse xenograft model at approximately 10 mg/kg per day as well as reduces tumor growth in the H69 SCLC mouse xenograft model