MW: 55,271 Da. Purity >95 % as determined by SDS-PAGE. Background: Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unus
Size
0.1 mg, 0.2 mg
Concentration
n/a
Applications
The recombinant human SIGIRR consists of 129 amino acids and has a predicted molecular mass of 14 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhSIGIRR is approximately 25-35 kDa due to glycosylation.