Purity >99%. An immunosuppressant. Selectively blocks signaling that leads to p70 S6 kinase activation (IC50 = 50 pM). Inhibits lymphokine-induced cell proliferation at the G1 phase. Induces apoptosis in a murine B cell line. Rapamycin has been used in vivo studies by i.p., i.m., and i.v. administrations..
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Other Names
Sirolimus, 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, AY 22989