1-628aa, Full length protein. MW: 64,741 Da. Purity >85% (SDS-PAGE). This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alter
[E3 SUMO-protein ligase PIAS3 isoform 3; E3 SUMO-protein ligase PIAS3; E3 SUMO-protein ligase PIAS3; protein inhibitor of activated STAT 3; E3 SUMO-protein transferase PIAS3Curated; Protein inhibitor of activated STAT protein 3]