MW: 17,888 Da. Purity >85% (SDS-PAGE). The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.
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Other Names
[E3 ubiquitin-protein ligase RBBP6 isoform 1; E3 ubiquitin-protein ligase RBBP6; E3 ubiquitin-protein ligase RBBP6; retinoblastoma binding protein 6, ubiquitin ligase; Proliferation potential-related protein; Protein P2P-R; RING-type E3 ubiquitin transferase RBBP6Curated; Retinoblastoma-binding protein 6; p53-associated cellular protein of testis]