MW: 83,612 Da. Purity >85% (SDS-PAGE). This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serinethreonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes a
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Other Names
[E3 ubiquitin-protein ligase RNF216 isoform A; E3 ubiquitin-protein ligase RNF216; E3 ubiquitin-protein ligase RNF216; ring finger protein 216; RING finger protein 216; RING-type E3 ubiquitin transferase RNF216Curated; Triad domain-containing protein 3; UbcM4-interacting protein 83; Ubiquitin-conjugating enzyme 7-interacting protein 1]