FAM-DEVD-OPH in vitro Apoptosis Detection Reagent, Pack of 4 Vials
Description
Description: Detect apoptosis in cultured cell settings with the green fluorescent caspase 3/7 inhibitor reagent, FAM-DEVD-OPH. FAM-DEVD-OPH: 5-FAM-Asp-Glu-Val-Asp(OMe)-Oph (2,6-diF) caspase 3/7 inhibitor; Pack of 4 Vials. Background: Apoptosis Detection with FAM-DEVD-OPH Caspase 3-7 Inhibitor Apoptosis is an evolutionarily conserved process of programmed cell suicide mediated by a cascade of proteolytic enzymes called caspases. Once activated in response to pro-apoptotic signals, caspases cleav
Slee, E. A., et. al. Serial killers: ordering caspase activation events in apoptosis. Cell Death Differ. 6:1067-1074 (1999) Thornberry,A., et. al. A combinatorial approach defines specificities of members of the caspase family and granzyme B. J Bio Chem. 272(29):17907-17911 (1997).Chauvier, D., et. al. Broad spectrum caspase inhibitors: from myth to reality? Cell Death Differ. 14:387-391 (2007). Callus, B. A. and Vaux, D. L. Caspase inhibitors:viral, cellular, and chemical. Cell Death Differ. 14