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Description
Monoclonal Antibody to detect Calnexin in human samples. It recognizes a protein of 90kDa, which is identified as Calnexin. Secretory and transmembrane proteins are synthesized on polysomes and translocate into the endoplasmic reticulum (ER) where they are often modified by the formation of disulfide bonds, amino-linked glycosylation and folding. To help proteins fold properly, the ER contains a pool of molecular chaperones including calnexin. It is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein
Immunogen
Recombinant N-terminal fragment of human Calnexin protein
Other Names
Calnexin; CANX; CNX; IP90; Major histocompatibility complex class I antigen-binding protein p88; P90