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Description
Mouse Anti-CBFA2T2 Recombinant Antibody (2C10). This product is antibody recognizes CBFA2T2. The antibody 2C10 immunoassay techniques such as: ELISA, IHC-F, WB. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to
Immunogen
Partial recombinant corresponding to aa201-304 from CBFA2T2 (NP_001028171.1) with GST tag. MW of the GST tag alone is 26kD
Other Names
CBFA2/RUNX1 Translocation Partner 2; Core-Binding Factor, Runt Domain, Alpha Subunit 2; Translocated To, 2; Myeloid Translocation-Related Protein 1; ETO Homologous On Chromosome 20; MTG8-Related Protein 1; MTG8-Like Protein; MTGR1;