If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
Mouse Anti-CBFA2T2 Recombinant Antibody (3A2). This product is antibody recognizes CBFA2T2. The antibody 3A2 immunoassay techniques such as: ELISA, WB. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for
Immunogen
CBFA2T2 (NP_001028171.1, 201 a.a. ~ 304 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: LLLNTSIASP ADSSELLMEV HGNGKRPSPE RREENSFDRD TIAPEPPAKR VCTISPAPRH SPALTVPLMN PGGQFHPTPP PLQHYTLEDI ATSHLYREPN KMLE
Other Names
CBFA2/RUNX1 Translocation Partner 2; Core-Binding Factor, Runt Domain, Alpha Subunit 2; Translocated To, 2; Myeloid Translocation-Related Protein 1; ETO Homologous On Chromosome 20; MTG8-Related Protein 1; MTG8-Like Protein; MTGR1;