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Description
Mouse Anti-CBFA2T2 Recombinant Antibody (3H3). This product is antibody recognizes CBFA2T2. The antibody 3H3 immunoassay techniques such as: ELISA, WB. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for
Immunogen
CBFA2T2 (AAH40344, 1aa-614aa) full-length recombinant protein with GST tag. MW of the GST tag alone is 26kD