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Description
Parkinson's disease is one of the most common neurodegenerative diseases and characterized by progressive loss of dopaminergic neurons. Leucine-rich repeat kinase 2 (LRRK2) is one of the genes responsible for autosomal dominant Parkinson's disease. LRRK2 gene codes a 280 kDa protein with 2,527 amino acid residues and has Leucine-rich repeats, Roc (Ras of complex proteins), COR, MAPKKK (mitogen-activated protein kinase kinase kinase) and WD40 domains. In recent studies, it has been reported that LRRK2 protein has a kinase activity and the activity increases by a mutation of LRRK2 gene. And the increase of kinase activity has been shown to induce neurologic toxicity. However, there are many unclear points about the functions of LRRK2 protein, and its role in the pathogenic mechanism of Parkinson's disease is still unknown. Description: Serum. Synonyms: Polyclonal LRRK2 antibody, Anti-LRRK2 antibody, Leucine-Rich Repeat Kinase 2 antibody.
Immunogen
LRRK2 antibody was raised in rabbit using a synthetic peptide corresponding to the C terminal part of human LRRK2 (HIEVRKELAEKMRRTSVE) as the immunogenSerum