Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) (C-Term)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human, mouse, rat, Xenopus laevis
Isotype
n/a
Format
affinity purified
Size
25 μL
Concentration
n/a
Applications
Western Blotting (WB),ELISA,Immunohistochemistry (IHC),Immunoprecipitation (IP)
Reviews / Ratings
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Description
Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphorylation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun.Synonyms: Death up-regulated gene protein antibody, Dug antibody, H731 antibody, Ma3 antibody, Neoplastic transformation inhibitor antibody, Neoplastic transformation inhibitor protein antibody, Nuclear antigen H731 antibody
Immunogen
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding amino acids near the carboxyl terminus of human Pdcd4 protein.Immunogen Type: Peptide