Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) (pSer457)
Clone
2E10-C12
Host Species
Mouse
Reactive Species
human, mouse, rat, Xenopus laevis
Isotype
IgG1 kappa
Format
unconjugated
Size
1 mg
Concentration
n/a
Applications
Western Blotting (WB),ELISA,Immunohistochemistry (IHC)
Reviews / Ratings
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Description
Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphoryl-ation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun. Ideal for researchers involved in Cell Signaling, Cancer and Signal Transduction research.Synonyms: Death up-regulated gene protein antibody, Dug antibody, H731 antibody, Ma3 antibody, Neoplastic transformation inhibitor antibody, Neoplastic transformation inhibitor protein antibody, Nuclear antigen H731 antibody
Immunogen
Anti-Pdcd4 phospho S457 Antibody was produced by repeated immunizations with a synthetic peptide corresponding to residues surrounding Ser457 of the human Pdcd4 protein.Immunogen Type: Peptide