N-2PIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-2PIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.06 and 0.125 μM, respectively.{8243,8513} It is over 400 times less potent as an inhibitor of ovine COX-1.{8513}