A neuropeptide and agonist of NPFF1 and NPFF2 receptors (Kis = 2.82 and 0.21 nM, respectively for human recombinant receptors); inhibits forskolin-induced cAMP production in CHO cells (EC50s = 236 and 2.3 nM, respectively); regulates baroreflex control of heart rate by activating oxytocin-releasing parvocellular PVN neurons; inhibits magnocellular PVN neurons; increases MAP briefly by 40 mm Hg in rats; has anti-opioid effects in rodent models, inhibiting morphine-induced analgesia and inducing abstinence in morphine-tolerant rats; also inhibits acquisition of conditioned place preference to cocaine in rats (10 and 20 nmol)