A ring-opened analog of wortmannin that potently and irreversible inhibits PI3K (IC50 = 0.1-88 nM); less potently blocks the activity of mTOR (IC50 = 3.1 μM); exhibits single agent in vivo anti-tumor activity and increases the anti-tumor effects of cisplatin and radiation treatment
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
inhibitors inhibits inhibitions cancers kinases proteins signal transductions intracellular signaling signals PXs 866 PX-866 PX866 ring-opened rings opened opens analogs wortmannin PI3K in vivo anti-tumors anti tumors antitumors cisplatin radiation treatments reduces reduction cells growth motility cytotoxicity PI3-Kinase PI3 10010591irreversible potent blocks mammalian targets rapamycin 13346 single agents activity effects three-dimensional 3D three dimensional cultures dosing patients increases diseases stable