A natural sesterterpenoid which reversibly inhibits sPLA2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation; at 1 μM, acts as an agonist for RAR α, β, and γ but not for other nuclear receptors; inhibits the activation of HIF-1 by hypoxia (IC50 = 3.6 μM)
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
111214-45-0 natural products inhibitors inhibits inhibitions phospholipases inflammation cancers hypoxia nuclears receptors sPLA2 isoforms sesterterpenoid secretory phospholipases A2 bee venom snake all-trans all trans retinoic acids RA agonist cancer cells lines RAR genes HIF-1 HIF1 HIFs one 1 nuclear receptors