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Description
ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene. This ETFA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276-304 amino acids from the C-terminal region of human ETFA.
Immunogen
Human ETFA.
Other Names
Electron Transfer Flavoprotein Alpha Polypeptide; ETFa; EMA; GA2; MADD; Glutaric Aciduria II; Electron transfer flavoprotein subunit alpha; mitochondrial; Alpha-ETF; electron-transfer-flavoprotein, alpha polypeptide; electron transfer flavoprotein alpha-subunit; electron transfer flavoprotein, alpha polypeptide