Poly (ADP-Ribose) Polymerase Family, Member 11 (PARP11)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human, mouse, rat
Isotype
n/a
Format
affinity purified
Size
50 μg
Concentration
n/a
Applications
Western Blotting (WB)
Reviews / Ratings
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Description
PARP1 encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. PARP1 can be cleaved resulting in fragements of 29 and 85 kDa.
Immunogen
PARP11 antibody was raised using a synthetic peptide corresponding to a region with amino acids IKHGNTFQIHGVSLQQRHLFRTYKSMFLARVLIGDYINGDSKYMRPPSKD