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Description
Mouse Anti-PYCARD Recombinant Antibody (1A2). Provided herein is a Mouse monoclonal antibody against Human PYD and CARD domain containing. The antibody can be used for immunoassay techniques, such as WB, FC. PYCARD is an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates
Immunogen
Full length human recombinant protein of human PYCARD (NP_037390) produced in E. coli