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Description
Monoclonal antibody to detect TNF alpha in human samples. The antibody binds specifically to TNF-alpha, a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB.
Immunogen
Human TNF-alpha
Other Names
Tumor necrosis factor superfamily member 2, TNFSF2, TNFA