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Description
Purified anti-TREM-2. TREM-2 is a 26 kD transmembrane glycoprotein that consists of a single extracellular immunoglobulin-like domain, a transmembrane region with a charged lysine residue and a short cytoplasmic tail. It associates with DNAX-activation protein 12 (DAP12) for signaling and function. TREM-2 is expressed on immature monocyte-derived dendritic cells. After activation by microbial products or tumor necrosis factor (TNF) and TNF-related proteins, dendritic cells downregulate the expression of TREM-2. TREM-2 is also expressed by osteoclasts and microglia, where it is involved in bone modeling and brain function, respectively. Another role of TREM-2 might be promoting the removal of apoptotic cells, organic matrix and macromolecules by microglia.
Immunogen
This monoclonal antibody was raised against a mouse recombinant TREM-2 protein.
Other Names
Trem2a, Trem2b, Trem2c, triggering receptor expressed on myeloid cells 2, triggering receptor expressed on monocytes 2, MRT-5093-1000