An agonist of the bile acid receptor TGR5 (EC50 = 1 μM) and blocks fatty liver development in cells and mice given ethanol; reduces NF-κB signaling and expression of miR-33 in LPS-treated macrophages, increasing levels of ABCA1; inhibits replication of HIV-1 (IC50 = 1.4 μM) and has cytotoxic effects against cancer cells