Recombinant Human CCR4-NOT transcription complex subunit 8 (CNOT8)
Description
Purity > 90% as determined by SDS-PAGE. MW: 60.5kDa. Full Length: 1-292aa. N-terminal GST-tagged. Homo sapiens (Human). Has 3'-5' poly (A) exoribonuclease activity for synthetic poly (A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.