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Description
Polyclonal antibody to detect endogenous levels of CTNND2 in human and mouse samples. Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB3. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.