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Description
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated and subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. CD8 is thought to play a role in the process of T-cell mediated killing.
Immunogen
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to near N-terminal residues of Cd8a protein.