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| Antigenic Specificity | CD1a Molecule (CD1A) (aa 158-173), (Middle Region) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD1A(Thymocyte antigen CD1A) also known as CD1, is a human protein encoded by the CD1A gene. CD1A is 1 of 5 distinct CD1 genes that are variably conserved in different mammalian species. This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex(MHC) proteins and form heterodimers with beta-2-microglobulin.The CD1A gene is mapped on 1q23.1. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. CD1A is concentrated in the early or recycling endosome. Moody et al.(2004) reported that CD1A presents to T cells a family of previously unknown lipopeptides from Mycobacterium tuberculosis, named didehydroxymycobactins because of their structural relation to mycobactin siderophores. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Apolipoprotein E(107741) binds lipid antigens and delivers them by receptor-mediated uptake into endosomal compartments containing CD1 in antigen-presenting cells. |
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| Immunogen | A synthetic peptide corresponding to a sequence in the middle region of human CD1a(158-173aa AKHFCKVLNQNQHEND). |
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| Other Names | CD1A|CD1.1|CD1.2|CD1A2|CD1|FCB6|HTA1|R4|T6|CD1B|AI747460|Cd1a|Cd1d|Ly-38 |
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| Gene, Accession # | Gene ID: 909 |
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| Catalog # | ABIN1673355 |
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| Price | |
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| Order / More Info | CD1a Molecule (CD1A) (aa 158-173), (Middle Region) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 2447586, 14739458, 10963609 |
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