A glycylcycline antibiotic; binds to the bacterial 30S ribosome, blocking the entry of transfer RNA, which halts protein synthesis and inhibits bacterial growth; active against a panel of 1,924 European clinical bacterial isolates (MICs = C. difficile cytotoxin activity and spore formation in cecum and colon in a mouse model of C. difficile infection at 6.25 mg/kg twice daily for 5 days ,