Purity ~90% (SDS-PAGE). Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Source: Recombinant protein corresponding to aa2-129 from human Histone H2A.J, fused to GST-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~40.9kD AA