A potent, reversible inhibitor of γ-secretase, reducing the cleavage of APP to Aβ40 in SH-SY5Y cells with an IC50 value of 5 nM; orally bioavailable and crosses the blood-brain barrier, as orally administered MK-0752 dose-dependently reduces the generation of new amyloid β protein in the brain of rhesus monkeys
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
952578-?68-?6 656810-87-6 biochemical inhibitor inhibit Alzheimer's research neuroscience cancer stem cell research MK0752 potent γ-secretase protease complex cleave single-pass transmembrane protein Notch receptor precursor β-amyloid APP domain reversible Aβ40 Aβ-40 cleavage reduce human neuroblastoma SH-SY5Y SHSY5Y orally bioavailable blood-brain barrier dose-dependently generation new rhesus monkey pathway breast cancer tumorgraft chemotherapy drug docetaxel mice tumor