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Description
Rabbit IgG polyclonal Picoband? antibody for MUC13 detection. Tested with WB, IHC-P, Direct ELISA in Human;Mouse;Rat. No cross reactivity with other proteins. Epithelial mucins, such as MUC13, are a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues. It is mapped to 3q21.2. Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. They often take an inhibitory role. Some mucins are associated with controlling mineralization, including nacre formation in mollusks,calcification in echinoderms and bone formation in vertebrates. They bind to pathogens as part of the immune system. Overexpression of the mucin proteins, especially MUC1, is associated with many types of cancer. Although some mucins are membrane-bound due to the presence of a hydrophobic membrane-spanning domain that favors retention in the plasma membrane, most mucins are secreted as principal components of mucus by mucous membranes or are secreted to become a component of saliva.
Immunogen
E.coli-derived human MUC13 recombinant protein (Position: E226-S312).
Other Names
Mucin-13; MUC-13; Down-regulated in colon cancer 1; MUC13; DRCC1; RECC; UNQ6194; PRO20221